Scientists from King’s College in London found that one of the drugs used for clinical treatment of Alzheimer’s disease may help the teeth to regenerate themselves from the inside, as a long-term it can lead to the eradication of caries.
When the tooth enamel cracks or opens a hole, the pulp which is located inside is exposed to the impacts in the mouth and can become infected, which contributes to toothache. In that case the stem cells contained in the pulp create a thin layer of dentin, a hard material which is located under the enamel and it prevents the appearance of infection.
This defensive system is inefficient for large damages, so you need to visit a dentist who will mechanically remove the damaged enamel and fill the tooth with inert material, usually cement or silicone.
This procedure weakens the tooth, which can be immobilized after multiple treatments, or may need to remove the tooth completely.
According to a study published in Scientific Reports, a team of scientists managed to encourage the development of stem cells using molecular Tideglusib, which is used as a medicine in clinical treatments for Alzheimer’s disease.
They used biodegradable sponges soaked with small doses that were put on mice on the damaged molars. After six weeks, the sponges were entirely collapsed, and the teeth managed to develop new dentin on the damaged area.
The research found that Tideglusib neutralize the impact of enzymes that normally prevent the development of dentin. “This drug is already approved and clinically proven and has been widely available, including the biodegradable sponges.
We have intentionally tried to do something that is really simple, quick and cheap. The fact that the drug has been proven in clinical research represents a real opportunity for this treatment to be delivered to dental offices as soon as possible. Said Paul Sharp, author of the study.
So far, this technique has been tested only in mice. The team plans to test it on rats, which have larger caries and larger molars before they switch to human subjects. Perhaps it is still early to seek treatment of stem cells from your dentist, but scientists hope that the simplicity of the treatment will soon make dentists to replace the invasive treatment with this regenerative procedure.